Mitochondrial Genome Quality Control

Mitochondrial DNA (mtDNA) is continuously exposed to damage and mutations due to its proximity to reactive metabolic processes. The accumulation of dysfunctional mtDNA molecules can impair mitochondrial function and contribute to cellular decline and disease. Our research investigates how cells maintain the integrity of their mitochondrial genomes through mechanisms of selective replication, turnover, and degradation. Using yeast as a model system, we combine quantitative genetics, live-cell imaging, and genomics to understand how cells recognize defective mtDNA molecules and ensure the propagation of functional mitochondrial genomes.