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mtDNA Intelligence Report

Automated curation of PubMed and bioRxiv literature focusing on mitochondrial genome organization, quality control, and yeast genetics.

Latest Report April 30, 2026

mtDNA Literature Briefing 2026-04-30

#mtDNA intel: • ER-mitochondria contact sites and manganese regulate mtDNA replication 🧬 • Long-read MitoScope resolves tissue-specific somatic variation and NUMTs • Nickel-VDAC1 binding activates cGAS-STING to drive aortic dissection 🔬 #mitochondria #genetics #cellbio

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Academic Disclaimer: This briefing is synthesized by Gemini 1.5 Pro AI based on abstracts. Podcasts are generated with NotebookLM. While designed to assist in literature monitoring, AI can misinterpret nuanced biological data. Full credit belongs to the authors of the primary research; we strongly encourage readers to consult the original publications linked in each dossier to ensure accurate data interpretation.

Briefing Archive

Apr 30, 2026

#mtDNA intel: • Manganese and ER-mitochondrial contact sites identified as key regulators of mitochondrial DNA replication. • Long-read MitoScope mapping reveals tissue-specific somatic variations and …

Apr 27, 2026

#mtDNA intel: • ER-mitochondrial contact sites and manganese regulate mtDNA replication • Membranes arrest the coarsening of mitochondrial condensates in human cells • mtDNA-cGAS/STING signaling …

Apr 23, 2026

#mtDNA intel: • DHCR24 deficiency triggers cytosolic mtDNA-mediated cGAS-STING activation. • PolRMT and TFAM structural interactions define mitochondrial transcription regulation. • SLC25A48 promotes colorectal cancer …

Apr 20, 2026

#mtDNA intel: • Mitochondrial translation elongation coordinates protein synthesis and folding to control OXPHOS biogenesis 🧬 • COX2-PGE2-PKA axis inhibits mtDNA-dependent STING activation to suppress …

Apr 16, 2026

#mtDNA intel: • Structural mapping reveals PolRMT and TFAM coordination in promoter transcription. • MitoScope long-read analysis resolves tissue-specific somatic variation and nuclear-embedded sequences. • …

Apr 13, 2026

#mtDNA intel: • Structural mapping of PolRMT-TFAM interactions defines promoter regulation 🧬 • ADT-OH mitigates cGAS-STING inflammatory cascades in microglia • Mitochondrial genomic variants identified …

Apr 09, 2026

#mtDNA intel: • Scalable ESC platform enables efficient generation of mtDNA mutant mouse models 🧬 • COX2-PGE2-PKA axis suppresses antiviral immunity by inhibiting mtDNA-STING signaling …

Apr 06, 2026

#mtDNA intel: • Membrane pearling drives nucleoid distribution in mammalian cells. • Identification of MTALTCO1, a novel 259-amino-acid protein encoded by the mitogenome. • Neuron-released …

Apr 02, 2026

#mtDNA intel: • MitoPerturb-Seq maps single-cell responses to mtDNA depletion and heteroplasmy 🧬 • Autophagy and bottleneck size regulate purifying selection during maternal inheritance • …

Mar 30, 2026

Structure-selective endonuclease drives uniparental inheritance mechanisms 🧬 • SCAD-mediated mtDNA leakage fuels antitumor immunity via demethylation • DCTPP1 regulates dCTP pool dynamics to maintain mtDNA …

Mar 26, 2026

Core replication machinery organizes into multiphasic condensates • mtDNA variants influence nuclear telomere length 🧬 • UV irradiation alters TFAM binding specificity and DNA compaction …

Mar 23, 2026

Structure-selective endonuclease drives uniparental mitochondrial inheritance. • Encapsulated mitochondrial transplantation reverses dysfunction in Parkinson's models 🧬. • VDAC1-mediated mtDNA release in keratinocytes triggers innate immunity …

Mar 19, 2026

Single-cell multi-omics tracks mitochondrial mutational mosaicism dynamics. • RNA Pol III sensing of mtDNA is essential for IFN immunity against SARS-CoV-2. • Atpif1 drives CAR-T …

Mar 16, 2026

AK4-mediated mtDNA synthesis regulates macrophage anti-bacterial activity. • PARKIN overexpression confers cardioprotection via mtDNA-cGAS-STING axis suppression. • Erythrocyte TLR9-ox-mtDNA binding links oxidative damage to systemic …

Mar 15, 2026

4 mt-tRNAs expressed from 2 loci • TLR9-ox-mtDNA binding drives MS inflammation • Butyrate extends life in mitochondrial deficiency 🧬🔬 #cellbio

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